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A Nutritional Approach to Alzheimer's DiseaseNutrients for Memory


The Hawaii Dementia Prevention Trial

Steve Blake, ScD

 

 

July, 2017

"It was good meeting you today and I very much appreciated your informative discussion of nutritional approaches to prevention and treatment of Alzheimer's disease and related dementias."
BRENT P. FORESTER, MD Instructor in Psychiatry, Harvard. Director Mood Disorders Division, Geriatric Psychiatry Research Program and Site Director, McLean Hospital,
Harvard Medical School.

      $9.95 to download the entire 183 page PDF book. Click below:

       

      Please see below for the table of contents and the scientific references.

      Read a two-page article on nutrition and Alzheimer's disease

      Table of Contents

      Introduction       2
      Table of Contents            4
      Table of figures 11
      Chapter 1: Diet can be powerful                13
      Age and delaying dementia         13
      The Nurses’ Health Study             14
      The MIND diet  15
      Rush Memory and Aging Project               16
      Supplements to improve cognition          18
      The Hawaii Dementia Prevention Trial    20
      Chapter 2: Overview of Alzheimer’s disease        24
      Changes to the brain in Alzheimer’s disease        25
      What are amyloid plaques           27
      Meet tau tangles             29
      An epidemic of Alzheimer’s disease        31
      Junk food, diabetes, and Alzheimer’s disease     33
      Diabetes and dementia risk         34
      Drugs and Alzheimer’s disease  34
      Prevalence of dementia               37
      Chapter 3: Food and nutrient changes that worked          40
      Vitamin E             40
      Advanced glycation endproducts              41
      Berries for memory        43
      Vascular dementia and saturated fat      44
      Supplements used in the trial     46
      Two B-vitamins 46
      SAMe    47
      Antioxidants      48
      Vitamin E supplement used        49
      Vitamin C supplement used        50
      Coenzyme Q10 51
      Four antioxidant minerals            52
      Two medical plants used              53
      Ginkgo biloba    54
      Centella asiatica (gotu kola)         54
      Chapter 4: Folate, vitamin B12, homocysteine, and SAMe             56
      How amyloid plaques are made                56
      How two B-vitamins reduce the formation of amyloid plaques   59
      Folate and vitamin B12 transform homocysteine into SAMe.       61
      Homocysteine and Alzheimer’s disease 62
      Are we getting enough Folate and Vitamin B12?                65
      Getting enough vitamin B12        66
      SAMe and Alzheimer’s disease  69
      Chapter 5: Advanced Glycation Endproducts       72
      Absorption of AGEs        73
      Formation of AGEs          74
      AGEs as a cause of brain damage in Alzheimer’s disease                79
      Cooking methods to reduce AGEs in food             81
      Chapter 6: Antioxidants and Alzheimer’s disease              83
      Vitamins E and C protect brain cell membranes from free radical attack  84
      Causes of excess free radicals    85
      Radiation and medical testing as sources of free radicals                86
      Plant Antioxidants Defend Us from Free Radicals              88
      Vitamin E and Alzheimer’s disease           88
      Why synthetic vitamin E is ineffective     90
      Food sources of vitamin E            95
      Vitamin C and Alzheimer’s disease           97
      Dietary sources of antioxidants 99
      Plant antioxidants            102
      Antioxidants made in your body               106
      Protecting our little energy factories, the mitochondria  109
      Coconut oil, ketones, and mitochondrial function             110
      Coenzyme Q10, the only fat-soluble antioxidant made in the body           113
      Are statins related to memory loss?        115
      Antioxidant content in diets        119
      Chapter 7: Saturated fat and dementia  121
      Saturated fat in diets      123
      Blood cholesterol and risk of Alzheimer’s disease             126
      Oxidized dietary cholesterol and vascular dementia         128
      Crystallized cholesterol 133
      Lowering cholesterol using phytosterols               135
      Fiber and blood cholesterol         138
      Chapter 8: Medical plants to treat Alzheimer’s disease   140
      Ginkgo biloba    140
      How does ginkgo work?                141
      How ginkgo protects brain cells 142
      Ginkgo and bleeding      143
      Ginkgo and memory       144
      Gotu kola            145
      Gotu kola as an antioxidant         146
      Gotu kola improves memory scores        146
      Gotu kola for memory in healthy elders                147
      Chapter 9: Exercise and Alzheimer’s disease       149
      Exercise and vascular dementia 150
      Muscle strength and Alzheimer’s disease             150
      Exercise decreases brain shrinkage          151
      Exercise can reduce risk of dementia      152
      Exercise can cut risk of dementia in half 152
      More exercise cuts risk further  153
      Chapter 11: Environmental toxins and Alzheimer’s disease           155
      Seafood, mercury, and DHA        155
      Organophosphate pesticides and dementia        158
      Organochlorines and dioxins       159
      Aluminum, does it cause Alzheimer’s disease?   160
      Chapter 10: Nutritional approaches to Alzheimer’s disease           162
      Acknowledgements       166
      Index    167
      Reference citations         172

       
      Table of figures
      Figure 1  Three supplements helped cognition   19
      Figure 2  Improvement in our trial            21
      Figure 3  No degeneration was noted with food changes               22
      Figure 4  Normal decline of memory score            22
      Figure 5  Normal brains on the left and advanced Alzheimer’s disease on the right            25
      Figure 6  Amyloid plaques look like fuzz balls between neurons.                27
      Figure 7   Amyloid plaques and tau tangles           28
      Figure 8  Tangled neuron looks like a fried egg    29
      Figure 9  The great increase in Alzheimer's death rate     31
      Figure 10 Dementia forecast for less developed countries            37
      Figure 11 Forecast increase in Alzheimer's disease            38
      Figure 12 Types of dementia graph          45
      Figure 13 Folate and vitamin B12 and amyloid plaque      57
      Figure 14 How amyloid plaque is formed               58
      Figure 15 Homocysteine and B-vitamins                60
      Figure 16 Folate can be low on an American diet                64
      Figure 17 Folate in food from the Diet Doctor      66
      Figure 18 Folate and vitamin B12 in diets               68
      Figure 19 List of foods highest in AGEs    77
      Figure 20 Synthetic vitamin E structure   92
      Figure 21 Nut and seed sources of vitamin E        96
      Figure 22 Vitamin E in some common foods         97
      Figure 23 Vitamin C in food graph             100
      Figure 24 Antioxidants in common diets                101
      Figure 25 A tiny amount of manganese on an Atkin's diet              108
      Figure 26 Cognitive performance among the elderly in relation to the intake of plant foods. The Hordaland Health Study.                120
      Figure 27 Saturated fat in various food servings 123
      Figure 28 A mostly clogged artery             125
      Figure 29 LDL diagram showing signaling proteins              131
      Figure 30 Cholesterol crystals in plaque  135
      Figure 31 Sources of plant sterols to block cholesterol     137

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